The primary aim of this pilot study is to conduct a series of N-­of-­1 trials comparing the effectiveness of:

  1. Evidence-­based advice (EBA)
  2. Paracetamol and EBA
  3. Naproxen and EBA
  4. Both paracetamol, naproxen, and EBA

to reduce daily neck pain and to prevent chronic pain at three months following whiplash injury in 15 'at-risk' individuals.

Intervention will commence as soon as possible but within two weeks of injury and continue for 12 weeks.

Why are we doing the study?

Whiplash creates a huge burden and enormous costs to Australia. Improved outcomes are urgently needed. Clinical guidelines recommend exercise, simple analgesia and evidence-based advice, but in practice, opioids are used too often and physiotherapy not enough. Also, several large randomised controlled trials (RCTs) show that so far nothing effectively prevents chronic pain. Why? Whiplash associated disorders (WAD) are heterogeneous. A one-size-fits-all approach is not working; novel individually targeted approaches are needed.

What do patients need to do?

Patients will need to:

  1. Take the study medication as instructed
  2. Complete questionnaires and symptom diaries for the duration of the study

What do I need to do?

  1. Give the patient a pamphlet (if you would like us to post you some pamphlets please contact
  2. If you have time, please ask patients to complete the permission to contact form and send it to

Benefits to patients 

Patients will be given a booklet containing exercises and advice on how to manage their pain that they can use throughout. After consultation with our trial GP, they will receive personalised medication report at the end of the trial.

Our results will give a probability of response and side effects to each treatment, which can guide treatment recommendations.

Benefits to practitioners who manage WAD

Results will be directly translatable to clinical practice, as these medications are readily available and recommended in WAD management guidelines.

What next?

For more information, please click on the link to read the study protocol and pamphlet.

Read the Information Sheet for Physiotherapists.

Thank you very much for your assistance!