Can pregabalin, if given early in acute whiplash, prevent chronic pain that can develop after a whiplash injury?

Summary

This study is a double blind, randomised, placebo-controlled trial comparing Pregabalin and advice (intervention) to Placebo and advice (control) for patients with acute whiplash injury. Eligible patients will be aged 18-65 yrs, within 48 hrs of whiplash injury, pain score ≥5 / 10, and not pregnant or breastfeeding.

Pregabalin or placebo will commence at 75 mg bd and be titrated up to 300 mg bd according to usual practice.

Intervention will commence as soon as possible but within 48hours of injury and continue for five weeks.

Results of the intervention will be supplemented by an economic evaluation of the direct and indirect costs incurred by the pregabalin + advice participants and those receiving placebo and advice.

View the detailed study overview [Word, 41KB].

Why become involved in this study?

Pregabalin has promise for treating acute whiplash injury and preventing the development of chronic pain, by preventing the development of central sensitisation.

If pregabalin is shown to be of benefit in preventing/modifying the development of chronic whiplash, and further evidence is obtained to support this finding, it may become standard practice to prescribe it in ED for acute whiplash, with resulting benefits for individuals and the Australian health care system.

What do I need to do?

  1. Watch a short presentation explaining key features and enrolment information [Powerpoint, 3MB]
  2. Peruse the Study Information Leaflet for Doctors [Word, 86KB]
  3. Read the protocol [Word, 296KB]
  4. Understand the study process, a brief step-by-step guide [Word, 33KB]
  5. Download the screening form [Word, 87KB] and patient consent form [Word, 81KB]

If you wish, you can view:

What next?

When you have finished reading about the study, please email scott.farrell@uq.edu.au to let us know you have done so.

Example email as follows:  "I have read the information about the Pregabalin trial and I am happy to be involved.  This includes being willing to obtain informed consent as needed.  I am happy to sign the delegation and training logs."  

Please ask us any queries you may have.

We will ask you for your signature on the delegation and training logs to document that you have read the study information and are willing to be involved.

Thank you very much for your assistance!